The mouse Na 1 - K 1 - ATPase g - subunit gene ( Fxyd 2 ) encodes three developmentally regulated transcripts
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چکیده
D. HOLSTEAD JONES,1 MICHAEL C. GOLDING,1 KEVIN J. BARR,1 GUO-HUA FONG,2 AND GERALD M. KIDDER1 1Departments of Physiology, Obstetrics and Gynaecology, and Paediatrics, University of Western Ontario, London N6A 5C1, and Child Health Research Institute, London N6C 2V5; and 2Lawson Research Institute, St. Joseph’s Health Centre, London, Ontario N6A 1Y5; and Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
منابع مشابه
Structural and functional interaction sites between Na,K-ATPase and FXYD proteins.
Several members of the FXYD protein family are tissue-specific regulators of Na,K-ATPase that produce distinct effects on its apparent K(+) and Na(+) affinity. Little is known about the interaction sites between the Na,K-ATPase alpha subunit and FXYD proteins that mediate the efficient association and/or the functional effects of FXYD proteins. In this study, we have analyzed the role of the tr...
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The Na,K-ATPase is an essential enzyme in the plasma membrane of all animal cells. The Na,K-ATPase catalyzes the efflux of three Na and the influx of two K ions per molecule of ATP hydrolyzed, thereby maintaining the steep transmembrane concentration gradients for Na and K that play a vital role in many biological processes. The functional enzyme is a heteromer composed of a primary catalytic ...
متن کاملNa,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability.
The gamma subunit of the Na,K-ATPase, a 7-kDa single-span membrane protein, is a member of the FXYD gene family. Several FXYD proteins have been shown to bind to Na,K-ATPase and modulate its properties, and each FXYD protein appears to alter enzyme kinetics differently. Different results have sometimes been obtained with different experimental systems, however. To test for effects of gamma in a...
متن کاملFXYD proteins: new regulators of Na-K-ATPase.
FXYD proteins belong to a family of small-membrane proteins. Recent experimental evidence suggests that at least five of the seven members of this family, FXYD1 (phospholemman), FXYD2 (gamma-subunit of Na-K-ATPase), FXYD3 (Mat-8), FXYD4 (CHIF), and FXYD7, are auxiliary subunits of Na-K-ATPase and regulate Na-K-ATPase activity in a tissue- and isoform-specific way. These results highlight the co...
متن کاملGestation changes sodium pump isoform expression, leading to changes in ouabain sensitivity, contractility, and intracellular calcium in rat uterus
Developmental and tissue-specific differences in isoforms allow Na+, K+-ATPase function to be tightly regulated, as they control sensitivity to ions and inhibitors. Uterine contraction relies on the activity of the Na+, K+ATPase, which creates ionic gradients that drive excitation-contraction coupling. It is unknown whether Na+, K+ATPase isoforms are regulated throughout pregnancy or whether th...
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تاریخ انتشار 2001